Search results for "Muscle degeneration"

showing 3 items of 3 documents

The Septum Inguinalis: A Clue to Hernia Genesis?

2018

Purpose: Double ipsilateral inguinal ("pantaloon") hernias and also the more advanced "combined" inguinal hernia involve disruption of the inguinal floor. In the case of pantaloon hernias, the medial boundary of the internal ring remains intact but in combined hernias this is fully disrupted, producing a single hernial protrusion. Deepening the pathophysiology of these hernias may be helpful in addressing hernia genesis, thus improving strategies for the treatment of this disease. Materials and Methods: A cohort of 22 patients who underwent inguinal hernia repair showed double ipsilateral (pantaloon) hernia, comprising distinct direct and indirect protrusions separated by a tissue septum. I…

Malearterial obstructionetiologynerve degenerationInguinal CanalHernia Inguinalhernia03 medical and health sciences0302 clinical medicineTissue markersmedicineHumansHerniaHerniorrhaphyAgedAged 80 and overNerve degenerationbusiness.industryAbdominal WallInguinal herniamuscle degenerationMuscle degenerationAnatomyArterial obstructionMiddle Agedmedicine.diseasedigestive system diseasesseptum inguinalisstomatognathic diseasesInguinal herniasurgical procedures operativemedicine.anatomical_structure030220 oncology & carcinogenesisFemale030211 gastroenterology & hepatologySurgerybusinessInferior epigastric vessels
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Optical Cross-Sectional Muscle Area Determination of <em>Drosophila Melanogaster</em> Adult Indirect Flight Muscles

2018

Muscle mass wasting, known as muscle atrophy, is a common phenotype in Drosophila models of neuromuscular diseases. We have used the indirect flight muscles (IFMs) of flies, specifically the dorso-longitudinal muscles (DLM), as the experimental subject to measure the atrophic phenotype brought about by different genetic causes. In this protocol, we describe how to embed fly thorax muscles for semi thin sectioning, how to obtain a good contrast between muscle and the surrounding tissue, and how to process optical microscope images for semiautomatic acquisition of quantifiable data and analysis. We describe three specific applications of the methodological pipeline. First, we show how the met…

0301 basic medicineGeneral Immunology and MicrobiologyGeneral Chemical EngineeringGeneral NeurosciencefungiMuscle degenerationBiologybiology.organism_classificationMuscle massmedicine.diseasePhenotypeMyotonic dystrophyGeneral Biochemistry Genetics and Molecular BiologyMuscle atrophy03 medical and health sciences030104 developmental biologymedicineDrosophila melanogastermedicine.symptomWastingProcess (anatomy)NeuroscienceJournal of Visualized Experiments
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Control of apterous by vestigial drives indirect flight muscle development in drosophila

2003

0012-1606 (Print) Journal Article Research Support, Non-U.S. Gov't; Drosophila thoracic muscles are comprised of both direct flight muscles (DFMs) and indirect flight muscles (IFMs). The IFMs can be further subdivided into dorsolongitudinal muscles (DLMs) and dorsoventral muscles (DVMs). The correct patterning of each category of muscles requires the coordination of specific executive regulatory programs. DFM development requires key regulatory genes such as cut (ct) and apterous (ap), whereas IFM development requires vestigial (vg). Using a new vg(null) mutant, we report that a total absence of vg leads to DLM degeneration through an apoptotic process and to a total absence of DVMs in the …

MaleNerve Tissue Proteins/genetics/metabolismMuscle Fibers SkeletalMutantTranscription Factors/genetics/*metabolismmedicine.disease_causeMyoblastsTwist transcription factorMyoblasts/physiologyDrosophila ProteinsWings AnimalDevelopmentalCells CulturedRegulator geneRegulation of gene expressionWing/growth & development/physiologyMutationCulturedMusclesGene Expression Regulation DevelopmentalNuclear ProteinsDrosophila Proteins/genetics/*metabolismAnatomyMuscle degenerationCell biologytwistDrosophilacutMuscles/metabolism/pathology/*physiologyIndirect flight musclesCellsLIM-Homeodomain ProteinsMuscle Fibers/pathology/physiologyNerve Tissue ProteinsBiologyvestigialNuclear Proteins/genetics/*metabolismmedicineHomeodomain Proteins/genetics/*metabolismAnimalsDrosophila/*growth & developmentDrosophilaMolecular BiologyHomeodomain ProteinsTwist-Related Protein 1Cell Biologybiology.organism_classificationapterousTwist Transcription FactorGene Expression RegulationMutationEctopic expressionTranscription FactorsDevelopmental BiologyDevelopmental Biology
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